Unique
supplements
supporting male fertility
Infertility affects 15% of couples and affects all races. Men account for 50% of pregnancy failures
Coenzyme Q10
Infertility affects 15% of couples and affects all races. The male is responsible for 50% of pregnancy failures, but in 30% of cases of male infertility the underlying causes are unknown (idiopathic infertility). In 30-80% of cases, oxidative stress (OS) is one of the factors causing idiopathic male infertility. OS is the effect of the depletion of the antioxidant capacity of the sperm caused by the imbalance between pro-oxidants and antioxidants in the seminal plasma. Reactive oxygen species (ROS) are essential for some physiological processes, such as sperm capacitation, acrosome reaction and fertilization. Excessive ROS production can damage the sperm plasma membrane by lipid peroxidation, induces sperm DNA fragmentation (SDF), impairs motility and viability, which ultimately reduces the potential for fertilization. The therapeutic role of antioxidants in the treatment of male infertility has been studied for many years. A good therapeutic effect of using non-enzymatic antioxidants, vitamins C, E, B12, D, coenzyme Q10, folic acid, selenium, L-carnitine, L-arginine, inositols or alpha-lipoic acid, has been documented. Hence, in the guidelines of scientific societies dealing with the treatment of infertility, despite the small number of randomized studies, there are recommendations for the use of antioxidants (LE item 1b).
Coenzyme Q10 (CoQ10)
Occurs in two forms: ubiquinone (oxidized) and ubiquinone (reduced). In blood plasma, there is over 90% of the reduced form, which has antioxidant effects. CoQ10 is a component of the respiratory chain, acts against hydrogen peroxide and other inflammatory markers of migraine along with the reduction of expression cytokines. It is found in human seminal fluid. It has an antioxidant function, participates in mitochondrial bioenergetics and metabolic processes. CoQ10 deficiency can lead to sperm damage, reduced sperm motility and sperm count. Studies and clinical trials have shown that CoQ10 supplementation can improve reproductive outcomes in men with fertility problems. In addition, the concentration of CoQ10 in seminal fluid correlates positively with sperm motility and count.
The dosage of Coenzyme Q10 given in the literature for the treatment of male infertility ranges from 150 to 400 mg/day. Lower doses, e.g. 100-200 mg/day in the treatment of chronic congestive heart failure, and in the prevention of migraine attacks from 30 to 800 mg/day, which indicates good tolerance of ubiquinone by the human body.
pismiennictwo-tytul:
Takalani NB, Monageng EM, Mohlala K, Monsees TK, Henkel R, Opuwari CS. Role of oxidative stress in male infertility. Reprod Fertil. 2023 Jul 7;4(3):e230024. doi: 10.1530/RAF-23-0024. PMID: 37276172; PMCID: PMC10388648
Kaltsas A. Oxidative Stress and Male Infertility: The Protective Role of Antioxidants. Medicina (Kaunas). 2023 Oct 4;59(10):1769. doi: 10.3390/medicina59101769. PMID: 37893487; PMCID: PMC10608597
Pavuluri H, Bakhtiary Z, Panner Selvam MK, Hellstrom WJG. Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches. Medicina (Kaunas). 2024 Jun 20;60(6):1008. doi: 10.3390/medicina60061008. PMID: 38929625; PMCID: PMC11205999
Wytyczne Europejskiego Towarzystwa Urologicznego 2024, www.uroweb.com
Alahmar AT, Calogero AE, Sengupta P, Dutta S. Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia. World J Mens Health. 2021 Apr;39(2):346-351. doi: 10.5534/wjmh.190145. Epub 2020 Jan 20. PMID: 32009311; PMCID: PMC7994657
Lucignani G, Jannello LMI, Fulgheri I, Silvani C, Turetti M, Gadda F, Viganò P, Somigliana E, Montanari E, Boeri L. Coenzyme Q10 and Melatonin for the Treatment of Male Infertility: A Narrative Review. Nutrients. 2022 Nov 1;14(21):4585. doi: 10.3390/nu14214585. PMID: 36364847; PMCID: PMC9658523
Soja AM, Mortensen SA. Behandling af kronisk hjerteinsufficiens med coenzym Q10 belyst ved metaanalyser af klinisk kontrollerede undersøgelser [Treatment of chronic cardiac insufficiency with coenzyme Q10, results of meta-analysis in controlled clinical trials]. Ugeskr Laeger. 1997 Dec 1;159(49):7302-8. Danish. PMID: 9417729
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